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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis

Fig. 2

The contribution of DHCR24 to Alzheimer’s disease. The downregulation of DHCR24 could be induced by risk factors from FAD and SAD, including Aβ, aging, diabetes-related risk factors, chronic hypoxia, oxidative stress, chronic inflammation, insufficiency of brain neurotrophic substances, and metabolic syndrome, suggesting a causative link between DHCR24 downregulation and major risk factors from AD. Furthermore, DHCR24 downregulation lead to the inhibition of cholesterol synthesis and decrease of cholesterol level in the plasma membrane and intracellular organelles, resulting in cholesterol deficiency-induced pathological impairments, such as Aβ overproduction, tau hyperphosphorylation, apoptosis, synaptic impairment, and other pathological impairments, which are associated with neurodegenerative diseases such as AD. Thus, the downregulation of DHCR24 could contribute to Alzheimer’s disease and other neurodegenerative diseases

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