Fig. 4
From: A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis
GSEA ranking and validation of targets identified by RNA-sequencing in EZH2 GOF tumors. a. Hallmark positive enrichment for ‘oxidative phosphorylation’ and negative enrichment for ‘KRAS signaling’ bar plots and scores are shown. b. Volcano plot showing the enrichment of genes in the EZH2 GOF tumors. c. Validation of RNA-seq targets by qRT-PCR (top, p < 0.05, unpaired t-test, n = 3 tumors/group) and cropped images of western blot (bottom) show significant expression of Idh1 (qPCR fold change = 2.5)