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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss

Fig. 7

Lysosome defects in glial cells in the cerebellum of aged Tmem106b−/− mice. a, b Cerebellar sections from 16-month‐old WT and Tmem106b−/− mice were immunostained with IBA1 and Cath D antibodies. Representative images from the DCN region are shown. The intensity of Cath D in IBA1-positive microglia was quantified in b. n = 3. ***, p < 0.001, unpaired t-test. Scale bar = 10 μm. c, d Cerebellar sections from 16-month‐old WT and Tmem106b−/− mice were immunostained with GFAP and Cath D antibodies. Representative images from the DCN region are shown. The intensity of Cath D in GFAP-positive astrocytes was quantified in d. n = 3. ****, p < 0.0001, unpaired t-test. Scale bar = 10 μm

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