Fig. 2From: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusionsThe peptides of huntingtin and EGFP were identified in the NIIs obtained from HD190QG mouse brains. a Huntingtin and EGFP were found only in the NIIs obtained from HD190QG transgenic mouse brains by LC–MS/MS. A modification 1xGG [K5] indicates that lysine 6 of huntingtin is ubiquitinated in insoluble nHTT inclusions. TG refers to HD190QG transgenic mouse samples, and WT refers to wild type. Abs refers to abundances. b The sequence of nHTT-EGFP with expanded polyglutamine (190Q) is shown, and the peptides identified by LC–MS/MS are underlined. The highlighted sequence was found both in mouse and human huntingtinBack to article page