Fig. 6
From: Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
Mislocalization of NR2B in AD patients is replicated by ADPHF transduction in vitro and ameliorated by TBB Immunocytochemistry of synaptic (NR2B-PSD95 colocalization) and extrasynaptic NR2B (white arrows) in ADPHF treated hippocampal neurons. Neurons were treated with a PBS, b TBB, c ADPHF for 14 days in vitro (DIV), d ADPHF 14DIV and TBB, e ADPHF for 7DIV, f ADPHF 7DIV and TBB; scale bar = 50 µm. g Quantification of NR2B normalized to DAPI. h Quantification of synaptic NR2B normalized to DAPI. **p < 0.01, ****p < 0.0001, one-way ANOVA followed by Tukey post hoc test. n = 5/group