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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization

Fig. 5

Inhibition of CK2 decreases ADPHF induced tau pathology. Immunocytochemistry of aggregated endogenous mouse tau in A DPHF treated hippocampal neurons. The mouse tau-specific antibody R2295M was used to visualize and quantify tau pathology. Neurons were treated with a PBS, b TBB, c ADPHF for 14 days in vitro (DIV), d ADPHF 14DIV and TBB, e ADPHF fo r 7DIV, f & g ADPHF 7DIV and TBB; scale bar = 50 µm. h Quantification of mouse tau (R2295M) normalized to DAPI. ***p < 0.001, * ***p <  0.0001, one- way ANOVA followed by Tukey post hoc test. n = 5/group

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