Fig. 2
From: Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
NR2B selectively translocates and correlates with AD-tau. Hippocampal tissue samples from tauopathy patients and age-matched controls were stained with NR2B and counterstained with DAPI. a Quantification of NR2B-positive tissue normalized to DAPI from control (age-matched, Braak ≤ 2) (n = 3), AD (n = 8), CBD (n = 6), PSP (n = 8), Pick’s (n = 6) patient samples. n.s. = nonsignificant; one-way ANOVA followed by Tukey post hoc test. b NR2B-positive tissue correlated with PHF1, normalized to DAPI from AD (n = 8) hippocampal samples. *p < 0.05, Pearson’s correlation. c Quantification of NR2Bser1480-positive tissue normalized to DAPI from control (n = 8), AD (n = 12), CBD ( n = 8), PSP (n = 8), and Pick’s (n = 5) patient samples. ****p < 0.0001, one-way ANOVA followed by Tukey post hoc test. d–f IHC of NR2Bser1480 and PHF1 in AD hippocampus; scale bar = 50 µm; white arrows indicate colocalization. NR2Bser1480-positive tissue correlated with PHF1, normalized to DAPI from AD patient tissue in g DG and h CA3. NR2Bser1480 and PHF1-positive tissue correlated with PHF1, normalized to DAPI from AD patient tissue in i DG and j CA3. *p < 0.05, **p < 0.01, Pearson’s correlation; n = 12