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Table 3 Species of circPSEN1 characterization and differences across groups

From: Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

circPSEN1 species   Discovery Replication Joint
ADADvsCO ADADvsAD ADvsCO ADADvsCO ADADvsAD ADvsCO ADADvsCO ADADvsAD ADvsCO
hsa_circ_0008521 P value 1.760 × 10–03 6.691 × 10–03 0.278 0.500 0.368 0.453 2.572 × 10–04 2.196 × 10–03 0.244
log2 FC 0.923 0.594 0.300 0.861 0.794 0.420 0.955 0.719 0.311
hsa_circ_0003848 P value 0.017 0.025 0.180 0.171 0.190 0.876 1.647 × 10–03 6.965 × 10–03 0.519
log2 FC 0.756 0.455 0.295 1.731 1.325 − 0.100 0.871 0.618 0.164
hsa_circ_0007013 P value 0.819 0.854 0.386 0.847 0.725 0.875 0.859 0.638 0.566
log2 FC − 0.298 − 0.124 0.766 0.628 0.665 0.172 0.195 0.319 0.381
circPSEN1 73147795–73165413 P value – – – 0.833 0.992 0.929 – – –
log2 FC – – – − 0.819 − 0.104 − 0.540 – – –
hsa_circ_0002564 P value 0.065 4.848 × 10–04 0.706 0.580 0.555 0.541 0.036 7.998 × 10–03 0.388
log2 FC 0.740 0.858 0.126 0.412 0.344 0.208 0.701 0.636 0.211
hsa_circ_0008218 P value – – – 0.943 0.667 0.801 – – –
log2 FC – – – − 0.277 0.733 − 0.255 – – –
hsa_circ_0032509 P value 0.816 0.840 – – – – – – –
log2 FC 0.717 0.640 0.207 – – –    
  1. Bold values denote nominal significance (P < 0.05)
  2. ADAD autosomal dominant Alzheimer's disease, AD sporadic Alzheimer's disease, CO control, PSEN1 Presenilin 1
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Acta Neuropathologica Communications

ISSN: 2051-5960

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