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Table 3 Species of circPSEN1 characterization and differences across groups

From: Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

circPSEN1 species

 

Discovery

Replication

Joint

ADADvsCO

ADADvsAD

ADvsCO

ADADvsCO

ADADvsAD

ADvsCO

ADADvsCO

ADADvsAD

ADvsCO

hsa_circ_0008521

P value

1.760 × 10–03

6.691 × 10–03

0.278

0.500

0.368

0.453

2.572 × 10–04

2.196 × 10–03

0.244

log2 FC

0.923

0.594

0.300

0.861

0.794

0.420

0.955

0.719

0.311

hsa_circ_0003848

P value

0.017

0.025

0.180

0.171

0.190

0.876

1.647 × 10–03

6.965 × 10–03

0.519

log2 FC

0.756

0.455

0.295

1.731

1.325

− 0.100

0.871

0.618

0.164

hsa_circ_0007013

P value

0.819

0.854

0.386

0.847

0.725

0.875

0.859

0.638

0.566

log2 FC

− 0.298

− 0.124

0.766

0.628

0.665

0.172

0.195

0.319

0.381

circPSEN1 73147795–73165413

P value

0.833

0.992

0.929

log2 FC

− 0.819

− 0.104

− 0.540

hsa_circ_0002564

P value

0.065

4.848 × 10–04

0.706

0.580

0.555

0.541

0.036

7.998 × 10–03

0.388

log2 FC

0.740

0.858

0.126

0.412

0.344

0.208

0.701

0.636

0.211

hsa_circ_0008218

P value

0.943

0.667

0.801

log2 FC

− 0.277

0.733

− 0.255

hsa_circ_0032509

P value

0.816

0.840

log2 FC

0.717

0.640

0.207

   
  1. Bold values denote nominal significance (P < 0.05)
  2. ADAD autosomal dominant Alzheimer's disease, AD sporadic Alzheimer's disease, CO control, PSEN1 Presenilin 1