Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

Table 3 Species of circPSEN1 characterization and differences across groups

circPSEN1 species		Discovery			Replication			Joint
circPSEN1 species		ADADvsCO	ADADvsAD	ADvsCO	ADADvsCO	ADADvsAD	ADvsCO	ADADvsCO	ADADvsAD	ADvsCO
hsa_circ_0008521	P value	1.760 × 10^–03	6.691 × 10^–03	0.278	0.500	0.368	0.453	2.572 × 10^–04	2.196 × 10^–03	0.244
hsa_circ_0008521	log₂ FC	0.923	0.594	0.300	0.861	0.794	0.420	0.955	0.719	0.311
hsa_circ_0003848	P value	0.017	0.025	0.180	0.171	0.190	0.876	1.647 × 10^–03	6.965 × 10^–03	0.519
hsa_circ_0003848	log₂ FC	0.756	0.455	0.295	1.731	1.325	− 0.100	0.871	0.618	0.164
hsa_circ_0007013	P value	0.819	0.854	0.386	0.847	0.725	0.875	0.859	0.638	0.566
hsa_circ_0007013	log₂ FC	− 0.298	− 0.124	0.766	0.628	0.665	0.172	0.195	0.319	0.381
circPSEN1 73147795–73165413	P value	–	–	–	0.833	0.992	0.929	–	–	–
circPSEN1 73147795–73165413	log₂ FC	–	–	–	− 0.819	− 0.104	− 0.540	–	–	–
hsa_circ_0002564	P value	0.065	4.848 × 10^–04	0.706	0.580	0.555	0.541	0.036	7.998 × 10^–03	0.388
hsa_circ_0002564	log₂ FC	0.740	0.858	0.126	0.412	0.344	0.208	0.701	0.636	0.211
hsa_circ_0008218	P value	–	–	–	0.943	0.667	0.801	–	–	–
hsa_circ_0008218	log₂ FC	–	–	–	− 0.277	0.733	− 0.255	–	–	–
hsa_circ_0032509	P value	0.816	0.840	–	–	–	–	–	–	–
hsa_circ_0032509	log₂ FC	0.717	0.640	0.207	–	–	–

Bold values denote nominal significance (P < 0.05)
ADAD autosomal dominant Alzheimer's disease, AD sporadic Alzheimer's disease, CO control, PSEN1 Presenilin 1

ISSN: 2051-5960