| |
Circular PSEN1
|
Linear PSEN1
|
|---|
|
log2FC
|
P value
|
log2FC
|
P value
|
|---|
|
ADAD versus controls
|
|
Discovery
|
0.799
|
3.93 × 10–04
|
0.217
|
0.078
|
|
Replication
|
0.722
|
0.142
|
− 0.235
|
0.361
|
|
Joint Analysis
|
0.794
|
1.63 × 10–04
|
0.261
|
0.062
|
|
ADAD versus AD
|
|
Discovery
|
0.522
|
6.17 × 10–03
|
0.163
|
0.126
|
|
Replication
|
0.735
|
0.113
|
− 0.137
|
0.597
|
|
Joint Analysis
|
0.602
|
8.22 × 10–04
|
0.128
|
0.332
|
|
AD versus controls
|
|
Discovery
|
0.289
|
0.208
|
0.101
|
0.434
|
|
Replication
|
0.171
|
0.540
|
− 0.199
|
0.172
|
|
Joint Analysis
|
0.186
|
0.303
|
− 0.082
|
0.442
|
- Bold values denote nominal significance (P < 0.05)
- ADAD autosomal dominant Alzheimer's disease; AD sporadic Alzheimer's disease; PSEN1 presenilin 1
