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Table 2 Differential expression results

From: Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

 

Circular PSEN1

Linear PSEN1

log2FC

P value

log2FC

P value

ADAD versus controls

Discovery

0.799

3.93 × 10–04

0.217

0.078

Replication

0.722

0.142

− 0.235

0.361

Joint Analysis

0.794

1.63 × 10–04

0.261

0.062

ADAD versus AD

Discovery

0.522

6.17 × 10–03

0.163

0.126

Replication

0.735

0.113

− 0.137

0.597

Joint Analysis

0.602

8.22 × 10–04

0.128

0.332

AD versus controls

Discovery

0.289

0.208

0.101

0.434

Replication

0.171

0.540

− 0.199

0.172

Joint Analysis

0.186

0.303

− 0.082

0.442

  1. Bold values denote nominal significance (P < 0.05)
  2. ADAD autosomal dominant Alzheimer's disease; AD sporadic Alzheimer's disease; PSEN1 presenilin 1
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Acta Neuropathologica Communications

ISSN: 2051-5960

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