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Table 2 Differential expression results

From: Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

  Circular PSEN1 Linear PSEN1
log2FC P value log2FC P value
ADAD versus controls
Discovery 0.799 3.93 × 10–04 0.217 0.078
Replication 0.722 0.142 − 0.235 0.361
Joint Analysis 0.794 1.63 × 10–04 0.261 0.062
ADAD versus AD
Discovery 0.522 6.17 × 10–03 0.163 0.126
Replication 0.735 0.113 − 0.137 0.597
Joint Analysis 0.602 8.22 × 10–04 0.128 0.332
AD versus controls
Discovery 0.289 0.208 0.101 0.434
Replication 0.171 0.540 − 0.199 0.172
Joint Analysis 0.186 0.303 − 0.082 0.442
  1. Bold values denote nominal significance (P < 0.05)
  2. ADAD autosomal dominant Alzheimer's disease; AD sporadic Alzheimer's disease; PSEN1 presenilin 1