Fig. 2

Global metabolic alterations in MB. A Unsupervised PCA-based multivariate analysis of CSF global metabolic profile between normal (n = 6) and MB (n = 28). B Volcano plot of differentially altered metabolites in MB compared with normal. C Relative abundance heatmap of highly altered metabolites in normal and different MBs, shown as a heatmap representation. Log2 FC, log2 fold-change; m/z, mass charge ratio; RT, retention time