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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation

Fig. 4

Molecular chaperones and co-chaperones closely associate with insoluble poly-GA DPR aggregates in human post-mortem brain tissue. Immunofluorescence co-staining for SQSTM1, HSPA8, VCP, UBXD1 and BAG3 (red) with poly-GA (green) and Hoechst (blue) in frontal cortex derived from neuropathologically diagnosed ALS and FTLD cases. Each staining is shown as a panel of single optical sections for red, green, and merged channels and an inset of the volume rendered z-stacks (3D). Scale bar: 5 µm

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