Table 1 Clinicopathological characteristics of the tumours included in the study, considered together and by cell lineage
All tumours n = 54 | Gonadotroph n = 26 | Pit1 lineage n = 20 | Corticotroph n = 8 | |
|---|---|---|---|---|
Age at surgery (years) | 56 (27–87) | 63 (37–87) | 49 (27–77) | 52 (33–66) |
Gender | ||||
Female | 32 (59%) | 12 (46%) | 14 (70%) | 6 (75%) |
Male | 22 (41%) | 14 (54%) | 6 (30%) | 2 (25%) |
Sample localization | ||||
Tumour tissue | 54 (100%) | 26 (100%) | 20 (100%) | 8 (100%) |
Adjacent anterior pituitary | 9 (17%) | 2 (8%) | 5 (25%) | 2 (25%) |
Maximal diameter (mm)* | 24 (5–60) | 30 (20–55) | 21 (7–60) | 15 (5–32) |
n = 45 | n = 22 | n = 16 | n = 7 | |
Invasion | ||||
Yes | 28 (52%) | 15 (58%) | 9 (45%) | 4 (50%) |
No | 18 (33%) | 7 (27%) | 9 (45%) | 2 (25%) |
NA | 8 (15%) | 4 (15%) | 2 (10%) | 2 (25%) |
Proliferation | ||||
No | 46 (85%) | 23 (88%) | 16 (80%) | 7 (88%) |
Yes | 8 (15%) | 3 (12%) | 4 (20%) | 1 (12%) |
Ki67 index | ||||
< 3% | 43 (80%) | 22 (85%) | 16 (80%) | 5 (62%) |
≥ 3% | 11 (20%) | 4 (15%) | 4 (20%) | 3 (38%) |
Mitosis | ||||
≤ 2/10 HPFs | 47 (87%) | 22 (85%) | 18 (90%) | 7 (88%) |
> 2/10 HPFs | 7 (13%) | 4 (15%) | 2 (10%) | 1 (12%) |
p53 | ||||
Negative | 43 (80%) | 24 (92%) | 12 (60%) | 7 (88%) |
Positive | 11 (20%) | 2 (8%) | 8 (40%) | 1 (12%) |
Grade | ||||
1a | 17 (31%) | 6 (23%) | 9 (45%) | 2 (25%) |
1b | 1 (2%) | 1 (4%) | 0 (0%) | 0 (0%) |
2a | 23 (43%) | 13 (50%) | 6 (30%) | 4 (50%) |
2b | 5 (9%) | 2 (8%) | 3 (15%) | 0 (0%) |
NA | 8 (15%) | 4 (15%) | 2 (10%) | 2 (25%) |
Functioning status | ||||
Functioning | 24 (44%) | 0 (0%) | 20 (100%) | 4 (50%) |
Non-functioning | 30 (56%) | 26 (100%) | 0 (0%) | 4 (50%) |