Table 1 Characteristics table of subjects with the mean (SD) listed for the continuous variables and count (%) for the categorical variables
From: White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition
Characteristics | MCSA n = 347 | ADRC n = 61 |
|---|---|---|
Demographics and cognition | ||
Age, yrs | 74.3 (8.5) | 74.4 (6.0) |
Males, no. (%) | 185 (53%) | 36 (59%) |
APOE4, no. (%) | 101 (31%) | 32 (71%) |
Education, yrs | 15.0 (2.6) | 16.0 (2.7) |
MMSE | 28.3 (1.8) | 21.9 (5.0) |
zGlobal | − 0.02 (1.41) | NA |
CDR | 0.2 (0.7) | 4.1 (2.9) |
Cognitively Impaired, no. (%) | 66 (19%) | 61 (100%) |
CVD markers | ||
WMH | 1.03 (1.04) | 1.35 (1.19) |
Hypertension, no. (%) | 221 (64%) | 27 (44%) |
Diabetes, no. (%) | 56 (16%) | 5 (8%) |
Dyslipidemia, no. (%) | 281 (81%) | 21 (34%) |
AD and TDP-43 markers | ||
PIB SUVr | 1.67 (0.48) | 2.43 (0.44) |
Tau SUVr | 1.23 (0.14) | 1.78 (0.46) |
FDG TDP-43a | 0.83 (0.06) | 0.87 (0.12) |
Diffusion Markers (NODDI and DTI models) | ||
Genu ISOVF | 0.11 (0.03) | 0.13 (0.03) |
Genu NDI | 0.54 (0.04) | 0.52 (0.04) |
ITWM NDI | 0.49 (0.04) | 0.47 (0.03) |
CGH NDI | 0.49 (0.03) | 0.46 (0.03) |