Antemortem detection of Parkinson’s disease pathology in peripheral biopsies using artificial intelligence

Table 7 Selected highest ranking AI features correlation with UPDRS score, CSF biochemistry, and dopamine transporter SPECT, Pearson r

AI features	MDS-UPDRS Part III, n = 55		MDS-UPDRS total, n = 55		DAT-SBR*, n = 56		CSF Synuclein, n = 53
AI features	r	p Value	r	p Value	r	p Value	r	p Value
LTS cluster size StDev	0.35	0.010	0.33	0.014	− 0.39	0.003	0.08	0.556
PreciseDx Graph Feature18	0.39	0.003	0.37	0.005	− 0.50	8.21E−05	0.14	0.303
StDev of Hematoxylin Channel	0.16	0.259	0.14	0.312	− 0.29	0.033	0.13	0.369
PreciseDx Graph Feature5	0.35	0.009	0.29	0.031	− 0.43	0.001	0.05	0.728
PreciseDx Graph Feature29	0.38	0.004	0.36	0.007	− 0.43	0.001	0.09	0.504
PreciseDx Graph Feature11	− 0.07	0.609	− 0.13	0.361	0.01	0.928	0.19	0.173
Davies-Bouldin Index	0.09	0.510	0.08	0.547	− 0.30	0.025	0.25	0.066
PreciseDx Graph Feature13	0.27	0.044	0.23	0.086	− 0.35	0.009	0.11	0.454
C Index	− 0.16	0.259	− 0.14	0.318	0.06	0.671	0.07	0.616
PreciseDx Graph Feature28	0.31	0.022	0.33	0.014	− 0.41	0.002	0.12	0.408
PreciseDx Graph Feature14	0.32	0.016	0.30	0.026	− 0.35	0.007	− 0.14	0.333
PreciseDx Graph Feature10	− 0.11	0.443	− 0.11	0.444	0.11	0.423	0.27	0.049
Calinski-Harabasz index	0.31	0.021	0.27	0.044	− 0.32	0.017	0.07	0.616
PreciseDx Graph Feature3	0.44	0.001	0.40	0.003	− 0.50	7.48E−05	0.07	0.625
PreciseDx Graph Feature27	0.36	0.006	0.34	0.011	− 0.50	8.11E−05	0.07	0.629

Statistically significant values are shown in bold
LTS Lewy type synucleinopathy, MDS-UPDRS Movement Disorders Society Unified Parkinson Disease Rating Scale
*DAT-SBR, dopamine transporter mean striatum specific binding ratio

ISSN: 2051-5960