Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: A novel LARGE1-AFF2 fusion expanding the molecular alterations associated with the methylation class of neuroepithelial tumors with PATZ1 fusions

Fig. 1

Radiological and histopathological features. A Axial T1-weighted magnetic resonance imaging image showing a left hyperintense temporal lesion. B Axial T1-weighted magnetic resonance imaging image after contrast injection showing an intense homogeneous enhancement of the lesion which is mainly solid with a small cyst (arrow). C Axial T2-weighted magnetic resonance imaging image showing an hypointensity of the lesion and a perilesional edema. D T2-FLAIR-weighted image showing the vasogenic perilesional edema. E Diffusion was not restricted. F The well delimitation of the tumor (HPS, magnification × 50). G The alternance of fibrous stroma containing few tumor cells and highest cellular areas (HPS, magnification × 200). H The collagenous stroma with few spindle cells (HPS, magnification × 400). I The cellular areas monomorphous cells with round to oval nuclei and abundant eosinophilic cytoplasm with microcystic changes (HPS, magnification × 400). J Low MIB-1 labeling index (magnification × 400). K GFAP immunoexpression by many tumor cells (magnification × 400). L MAP2 immunoexpression by a subset of tumor cells (magnification × 400). M Diffuse extravascular CD34 immunoexpression with CD34-positive ramified processes (magnification × 400). N Desmin immunoexpression by some tumor cells (magnification × 400). Black scale bars represent 500 µm for figure F, 250 µm for figure G, and 50 µm for figure H-N. HPS: Hematoxylin Phloxin Saffron.

Back to article page