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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Fig. 7

MRS5980 prevents cisplatin-induced changes in mitochondria related genes, neuronal cell death, apoptosis and necrosis. a Heatmap showing the expression pattern of mitochondrial related genes across four treatment groups. b Heatmap of the 164 overlapping genes between cisplatin vs PBS and cisplatin + MRS5980 vs cisplatin comparisons. c Top 3 functional enrichment pathways from cisplatin vs PBS and cisplatin + MRS5980 vs cisplatin comparisons. d The heatmap shows the expression pattern of transcription regulators from cisplatin vs cisplatin + MRS5980 comparison. The bar plot shows the top GO biological process identified based on transcription regulators

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