Fig. 6

RNAseq analysis of the transcriptome in the cortex after cisplatin and MRS5980. a Genes differentially expressed among groups is shown in a Venn diagram. Expression of 1,688 genes was changed in response to cisplatin when compared to the PBS mice (Cis vs PBS; n = 9–12). Expression of 528 genes was changed in response to cisplatin and MRS5980 administration vs. mice treated with cisplatin alone (Cis vs. Cis + MRS5980; n = 9–12). b Heatmap showing differential gene expression in response to cisplatin and cisplatin + MRS5980 treatment across all the samples. c Gene ontology (GO) biological process enrichment analysis of the 246 genes that were upregulated in the group treated with cisplatin + MRS5980 as compared to cisplatin alone. The size of the dot represents gene count and the color represents the p-value