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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

Fig. 2

Immunostaining of brain tissue from the FTLD-FET patient. a–d Immunohistochemical lesions in the hippocampus and frontal cortex. Ubiquitin immunolabeling displays rounded intra-cytoplasmic inclusions within the dentate gyrus (black arrows, a) but with no deformation of the nucleus [OM × 400]. Similar intra-cytoplasmic inclusions were observed in the anterior frontal cortex using FUS immunohistochemistry (black arrows, b), associated to FUS-positive either rounded (black arrow, c) or elongated granular intracytoplasmic inclusions (red arrow, c) [OM × 400] or filamentous curvilinear intranuclear inclusions in the dentate gyrus (black arrow, d) [OM × 400]. e TAF15 immunostaining displaying normal, finely granular nuclear staining (asterisk) contrasting with loss of TAF15 nuclear immunostaining resulting in cytoplasmic aggregates (black arrows) with f, intracortical neuritic accumulations (black arrow). OM: original magnification

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Acta Neuropathologica Communications

ISSN: 2051-5960

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