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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

Fig. 1

Representative macroscopic and microscopic findings from the FTLD patient’s brain. a External view of the right hemisphere showing frontal and temporal atrophy with sparing of the cingular cortex along with the parietal and occipital lobes. b–c Coronal sections passing through the atrophic caudate nucleus, putamen and pallidum (arrow, b) and atrophic hippocampus (arrow, c). d–g Histological examination [H&E, OM × 20] showing absent lamination of the anterior frontal cortex with vacuolization of layers II and III (arrow, d), severe gliosis in the caudate nucleus (e) and neuronal depletion replaced by gliosis of the CA1 field of the Ammon’s horn (arrows, f and g; H&E, OM × 20; OM × 100 respectively). H&E: haematoxylin and eosin stains; OM: original magnification

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Acta Neuropathologica Communications

ISSN: 2051-5960

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