Fig. 6

Acute minocycline administration reduces long-term neuronal and synapse loss. a Representative image of NeuN+ cells in CA3 region of injured hippocampi and b stereological quantification F(_{2, 21}) = 117.7, p < 0.0001. c Representative image of Iba1 cells in CA3 region of injured hippocampi and d stereological quantification F(_{2, 19}) = 52.5, p < 0.0001. e Representative image of myelin black gold staining and f quantification of percentage of myelinated area image of Iba1 cells in CA3 region of injured hippocampi and d stereological quantification F(_{2, 12}) = 24.92, p < 0.0001. g Puncta detection of PSD95 (red) synapsin (green). h Quantification of synaptic loci (% sham) F(_{2, 21}) = 12.14, p < 0.0003. One-way ANOVA followed by Tukey multiple comparison post hoc test were used to determine statistical differences; *p < 0.05. ***p < 0.01, ****p < 0.001, n = 5–9 per group