Fig. 2

Expression of inflammation and stress gene modules is enriched in normal appearing white matter. a Gene dendrogram and module colors of weighted gene correlation network analysis. b Heatmap depicting enrichment scores per module of expression-weighted cell type enrichment analysis. Color depicts enrichment score, asterisk indicates significant enrichments (p < 0.05). c–e Boxplots depicting module eigen genes for the ‘tan’, ‘midnightblue’ and ‘greenyellow’ gene modules. f–h Bar plots depicting gene ontology analysis of ‘tan’, ‘midnightblue’ and ‘greenyellow’ gene modules. *: p < 0.01; **: p < 0.001; ***: p < 0.0001. Abbreviations: CWM = control white matter (CTR donors); NAWM = normal appearing white matter (MS donors); WML = white matter lesion (MS donors)