Fig. 2

Clinical-pathological features, gene alterations and MMR status of 39 giant cells enriched GBMs. The matrix shows for each case the tumor mutational burden, mutational signature, gene alterations, immunohistochemical analysis of genes involved in DNA mismatch repair (MMR IHC) and the presence of microsatellite instability as assessed by MSI-PCR. Samples are sorted by the percentage of giant cells (30–49%; ≥ 50%) and then by ID number. Genes are grouped by pathway and then by frequencies of alterations and alphabetical order