Fig. 4
The CAA brain microvascular proteome displays a distinct profile independent of AD. a Venn diagram demonstrating the overlap between significantly altered proteins in CAA and AD (n = 12; p = 3.13 × 10–12). The overlapping proteins are displayed in yellow, the 23 and 70 proteins specifically altered in CAA and AD are shown in red and blue respectively. b Scatter plot of the log2 LFQ ratios in CAA versus CON against AD versus CON. Proteins exclusively altered in CAA are labeled with gene names, as are TNC and VGF. Significantly altered proteins are highlighted according to the colors in a, non-significantly altered proteins are shown in grey. c Circos diagram illustrating the subcellular localization information (UniProt) of the overlapping proteins and of the proteins specifically altered in CAA or AD