Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study

Table 5 Association between area deprivation and hallmarks of cerebrovascular disease

Adjusted Odds	Subcortical Cerebral Infarct(s) > 10 mm		Moderate/Severe Occipital Leptomeningial Cerebral Amyloid Angiopathy		Moderate/Severe Occipital White Matter Arteriosclerosis
Adjusted Odds	Odds Ratios	CI	Odds Ratios	CI	Odds Ratios	CI
IMD Stratum 2 vs 1	0.52	0.19 – 1.37	1.42	0.76 – 2.64	0.75	0.38 – 1.48
IMD Stratum 3 vs 1	1.08	0.41 – 2.86	0.86	0.42 – 1.79	1.32	0.64 – 2.71
IMD Stratum 4 vs 1	0.75	0.24 – 2.35	0.63	0.26 – 1.50	0.37	0.13 – 1.07
IMD Stratum 5 vs 1	1.33	0.50 – 3.56	2.55	1.18 – 5.53	1.09	0.47 – 2.52
Covariates:
Age at Death	1.04	1.00 – 1.08	1.02	1.00 – 1.05	1.03	1.00 – 1.06
APOE ε4 Carrier	0.69	0.35 – 1.36	2.74	1.69 – 4.44	1.03	0.62 – 1.72
Diabetes	0.40	0.11 – 1.43	0.76	0.35 – 1.68	1.13	0.51 – 2.49
Hypertension	0.75	0.39 – 1.44	1.18	0.73 – 1.91	1.17	0.71 – 1.95
Male Sex	2.42	1.18 – 4.98	1.70	1.02 – 2.82	1.48	0.87 – 2.53
Smoker	1.67	0.84 – 3.32	0.83	0.50 – 1.39	0.75	0.43 – 1.30
Alcohol Misuse	0.43	0.09 – 1.99	1.47	0.59 – 3.67	1.86	0.73 – 4.76

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