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Table 10 Brain region–specific amyloid volume (mm3) and amyloid load (%) in four DS age groups

From: Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Structures/ subdivisions

DS 26–41 y

DS 43–49 y

DS 51–59 y

DS 61–72 y

Volume

Load

Volume

Load

Volume

Load

Volume

Load

Entorhinal cortex—all layers

58.2

9.5

77.7

12.7

56.4

13.1

38.8

10.7

CA1

1.3

0.4

10.3

4.0

18.4

9.0

10.4

7.0

CA2

0.1

0.2

0.0

0.0

1.4

3.0

0.4

1.4

CA3

0.1

0.2

0.4

1.3

1.6

5.0

0.7

2.0

CA4

1.3

2.0

2.2

4.0

5.6

8.0

3.3

6.0

Subiculum

10.9

7.0

16.9

12.0

10.0

10.0

8.6

11.0

Amygdala

45.4

10.8

61.6

14.2

54.3

13.9

40.4

12.5

Thalamus

36.0

1.2

74.6

2.9

74.2

3.0

80.6

4.0

Substantia nigra

0.0

0.0

0.2

0.2

0.8

0.9

1.0

1.4

MBC

2.3

1.5

9.4

5.5

7.3

5.4

14.4

6.5

Caudate nucleus

81.8

3.6

189.9

11.2

140.0

9.5

222.7

15.0

Cerebellar cortex molecular layer

49.1

0.5

965.5

12.0

914.5

11.5

561.3

7.0

Dentate nucleus

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

Total (sum) Vol and mean load

286.5

2.8

1,408.6

6.1

1,284.5

7.1

974.3

6.5