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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Fig. 8

Neurofibrillary degeneration. Graphs a-e illustrate regional differences in the percentage of neurons with NFTs and the progression of neurofibrillary degeneration from the incipient stage in pre-AD (26- to 41-year-old DS subjects) to three stages of AD in the fourth, fifth, and sixth decades. Fig. e shows the ratio between the percentage of neurons with NFTs in pre-AD and in AD and the gradient of susceptibility of neurons, with the highest in the entorhinal cortex, cornu Ammonis, subiculum, and amygdala; lower in the MBC, thalamus, and substantia nigra; and marginal in the caudate and dentate nuclei. The general pattern is illustrated in fig. f and g, showing a plateau of the percentage of neurons with NFTs in the fifth and sixth decades. Decrease of the number of neurons with NFTs from 10.3 million in the fifth decade to 8.5 million in the sixth decade is evidence of the death and removal of neurons with NFTs

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