Fig. 4
Per-patient strain heterogeneity increases with advancing pathology. a Examples of per-patient vector distributions, showing varying amounts of heterogeneity among patients. Each plot contains all vectors for 1–6 individual patients, with the corresponding patient IDs labelled in the bottom left of each plot. Each point is the spectral vector representing a single plaque from the given patient. The columns contain DS, AD, and ADNC cases respectively. The rows contain cases with different Xtau in each cohort, which exemplifies how heterogeneity is greater in cases with more advanced pathology. No AD cases had Xtau = 0 and no ADNC cases had Xtau = 4. b–e KDEs of RMSDs calculated using each case’s vector distributions in PCs 2–4. These distributions are compared between b cohorts, c Xtau in DS, d Xtau in AD, and e AD and DS cases with Xtau = 4