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Table 3 Summary of comparisons between all pairs of experimental groups that differ by only a single subject or injury factor. Sarm1-KO = sterile alpha and toll-interleukin receptor motif containing 1

From: Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review

Parameter

Comparable groups

Summary of comparison of microglial activation in the white matter

Age

12a (24 weeks) vs. 12b (54 weeks) [36]

Increased in older group

12c (24 weeks) vs. 12d (54 weeks) [36]

Increased in younger group

24a (12 weeks) vs. 24b (50 weeks) [57]

Inconclusive comparison

24c (12 weeks) vs. 24d (50 weeks) [57]

Inconclusive comparison

Genotype

12a (APP/PS1) vs. 12c (WT) [36]

Increased in APP/PS1 group

12b (APP/PS1) vs. 12d (WT) [36]

Increased in wild-type group

02a (WT) vs. 02b (LIF heterozygous) [37]

Initial increase in wild-type group, delayed increase in LIF ( ±) group

20a (WT) vs. 20b (Sarm1-KO)) [50]

Inconclusive comparison

Inter-injury interval

21a (1 day apart) vs. 21c (2 days apart) [35]

Inconclusive comparison

Number of mTBIs

21a (1 mTBI) vs. 21b (5 mTBIs) [35]

Increased in group with more mTBIs

21a (1 mTBI) vs. 21c (5 mTBIs) [35]

Increased in group with more mTBIs

17a (1 mTBI) vs. 17b (2 mTBIs) vs. 17c (3 mTBIs) [43]

Highest in group with 2 mTBIs

13b (1 mTBI) vs. 13a (2 mTBIs) [44]

Inconclusive comparison

25a (1 mTBI) vs. 25b (5 mTBIs) [51]

Inconclusive comparison

15a (1 mTBI) vs. 15b (2 mTBIs) [58]

Inconclusive comparison

Sex

22a (males) vs. 22b (females) vs. 22c (mixed) [42]

Inconclusive comparison

24a (males) vs. 24c (females) [57]

Inconclusive comparison

24b (males) vs 24d (females) [57]

Inconclusive comparison

09b (males) vs. 09c (females) [54]

Inconclusive comparison

Weight

09a (37.5 g) vs. 09b (52.5 g) [54]

Inconclusive comparison

Other

10a (no mild ventriculomegaly) vs. 10b (mild ventriculomegaly) [59]

Inconclusive comparison