Fig. 4

Contextualizing microglial activation in white matter relative to other post-mTBI assessments. ‘Before’ and ‘after’ tallies refer to when an assessment resolved relative to the resolution of microglial activation. Instances where limited temporal range or resolution of the assessment obscured the relative orders of resolution were tallied as ‘Inconclusive’. Specific assessment descriptions are provided in Additional File 7. 5-HT1B = 5-hydroxytryptamine receptor 1B; 8-OHdG = 8-hydroxy-2’-deoxyguanosine; AD = axial diffusivity; ADC = apparent diffusion coefficient; APP = amyloid precursor protein; Arg-1 = arginase-1; BDA = biotinylated dextran amine; CD11b = cluster of differentiation molecule 11b; CD206 = cluster of differentiation 206; CD40 = cluster of differentiation 40; CD68 = cluster of differentiation 68; CD86 = cluster of differentiation 86; CNPase = 2’,3’-Cyclic-nucleotide 3’-phosphodiesterase; CV = cresyl violet; DAPI = 4’,6-diamidino-2-phenylindole; FA = fractional anisotropy; FJC = Fluoro-Jade C; GFAP = glial fibrillary acidic protein; IL-1β = interleukin 1 beta; IL-12 = interleukin 12; IL-6 = interleukin 6; iNOS = inducible nitric oxide synthase; Ka = axial kurtosis; Kr = radial kurtosis; LFB = luxol fast blue; MBP = myelin basic protein; MD = mean diffusivity; MK = mean kurtosis; MOG = myelin oligodendrocyte glycoprotein; mRNA = messenger ribonucleic acid; MTR = magnetization transfer ratio; NF200 = neurofilament protein; NF-L = neurofilament light protein; NG2 = neural/glial antigen 2; Nrf2 = NF-E2 DNA binding protein; Olig2 = oligodendrocyte transcription factor; PDGFRα = Platelet-derived growth factor receptor α; PLP = proteolipid protein 1; p-STAT3 = phospho-signal transducer and activator of transcription 3; p-tau = phospho-tau; qPCR = quantitative polymerase chain reaction; RA = relative anisotropy; RD = radial kurtosis; RNA = ribonucleic acid; TNF-α = tumor necrosis factor alpha; TNFR1 = tumor necrosis factor receptor 1; TNFR2 = tumor necrosis factor receptor 2; t-tau = total tau