Fig. 2

Distributions of common parameters among included studies. A Sexes of included subjects. Both = male and female subjects examined separately; Mixed = male and female subjects pooled together. B Species of included subjects. C Injury model used. CI = controlled piston-driven impact; WD = weight drop; CH = Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA); BI = blast injury; FPI = fluid pulse injury; HIFU = high-intensity focused ultrasound; LIM = lateral impact model. C = closed-skull; O = open-skull. D Analgesia administered following mTBI procedure. E Regions in which microglial activation in the white matter was quantified. F Methods used to quantify microglial activation in the white matter. CD11b = cluster of differentiation 11b; CD68 = cluster of differentiation 68; EM = electron microscopy; H = histology; mRNA = messenger ribonucleic acid; qPCR = quantitative polymerase chain reaction