Reference | Case no | Sex | Age (yrs) | Primary tumor location | MYC vs. MYCN amplification | Resection | Relapse/ Progression | Chemotherapy | Radiation therapy | Disease history |
---|---|---|---|---|---|---|---|---|---|---|
This study | 1 | M | 12 | Cervical/Thoracic | MYC (8q24) | GTR | Yes | Yes | Yes | Multiple recurrences, GTR of first resection at C6-T2; first recurrence at C2-T1/T2 11Â months post-resection treated with STR, chemotherapy and proton therapy; progression and metastasis to thoraco-lumbar region 16Â months after first relapse treated with IMRT to the entire thecal sac and focal re-irradiation to the cervical region tumor |
[49] | 1 | F | 22 | Cervical | MYCN (2p24) | STR | No | No | Unknown | Died, cause uncertain |
[49] | 2 | F | 31 | Lumbar | MYCN (2p24) | GTR | Yes | NA | Yes | Alive at 15- month follow-up |
[49] | 3 | F | 13 | Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Died of disease |
[49] | 4 | F | 15 | Thoracic | MYCN (2p24) | NA | NA | NA | NA | NA |
[20] | 1 | F | 14 | Cervical/Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Dead |
[20] | 2 | M | 18 | Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Alive at 111-month follow-up |
[20] | 3 | M | 12 | Cervical/Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Dead |
[20] | 4 | F | 35 | Cervical/Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Alive with palliative care (29-month follow-up) |
[20] | 5 | M | 34 | Lumbar | MYCN (2p24) | STR | Yes | Yes | Yes | Dead |
[20] | 6 | F | 26 | Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Alive at 31-month follow-up |
[20] | 7 | M | 23 | Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | NA |
[20] | 8 | F | 32 | Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Dead |
[20] | 9 | F | 56 | NA | MYCN (2p24) | GTR | NA | No | Yes | Dead |
[20] | 10 | M | 35 | Cervical/Thoracic | MYCN (2p24) | STR | No | Yes | Yes | Alive at 4-month follow-up |
[20] | 11 | M | 37 | Cervical/Thoracic | MYCN (2p24) | STR | No | No | Yes | Alive at 11-month follow-up |
[20] | 12 | F | 46 | Cervical | MYCN (2p24) | No | Yes | Yes | No | Alive at 2-month follow-up |
[20] | 13 | F | 16 | NA | MYCN (2p24) | NA | NA | NA | NA | Dead |
[41] | 1 | M | 52 | Thoracic/Brain | MYCN (2p24) | NA | NA | NA | NA | Alive at 2-month follow-up |
[41] | 2 | F | 24 | Cervical/Thoracic/Lumbar | MYCN (2p24) | NA | NA | NA | NA | Alive at 14-month follow-up |
[41] | 3 | F | 30 | Thoracic | MYCN (2p24) | GTR | Yes | Yes | No | Alive at 17-month follow-up |
[41] | 4 | M | 36 | Thoracic | MYCN (2p24) | STR | Yes | Yes | Yes | Alive at 55-month follow-up |
[41] | 5 | F | 37 | Thoracic | MYCN (2p24) | Resection | Yes | No | Yes | Alive at 62-month follow-up |
[41] | 6 | F | 35 | Cervical/Thoracic | MYCN (2p24) | STR | Yes | Yes | No | Alive at 63-month follow-up |
[41] | 7 | M | 52 | Cervical/Thoracic/Lumbar | MYCN (2p24) | Resection | Yes | Yes | No | Dead |
[41] | 8 | M | 29 | Cervical | MYCN (2p24) | STR | Yes | Yes | Yes | Dead |
[43] | 13 | F | 40 | Spinal | MYCN (2p24) | NA | Yes | NA | NA | NA |