Fig. 9From: Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer diseaseRepresentation of the amino acids associated with missense variants on the molecular surface of the wild-type human SorLA Vps10p domain (PDB ID 3WSY). Positions associated with impaired maturation are colored in red, those which have no effect are colored in blue. a Top view; b Bottom View; c, d Rotation by 90° around the vertical or horizontal axes of (A) representation. The G543E variant, which is totally buried, is not observableBack to article page