Fig. 6

STAT3 inhibition reduces neuroinflammation in 5XE4 mouse model of AD. The mouse brain sections were immunostained with IBA-1 and GFAP for microgliosis and astrocytosis, respectively. Proinflammatory cytokines (IL-1β and TNFα) levels in mice brain were also measured using appropriate ELISA kits. A, B Photomicrographs of immunostaining of GFAP (a marker of astrocyte) and IBA-1 (a marker for microglia). C, D Quantification of relative intensity of GFAP and IBA-1. Scale bars represent 100 mm for brain section. E IL-1β levels in mice brain. F TNFα levels in mice brain. Data is presented as mean ± SEM, *p < 0.05, **p < 0.01, a- as compared to veh + WT, b- as compared to veh + 5XE4, n = 9–10 in each group, veh- vehicle, WT- wild-type, 5XE4- 5XFAD/APOE4