Fig. 5

STAT3 inhibition reduces oxidative stress and oxidative modification of LRP-1 and restores LRP-1 level in 5XE4 mouse model of AD. A Oxidative stress was assessed by measuring TBARS levels in mice brain. Data is presented as mean ± SEM. #p < 0.05 as compared to veh + WT, *p < 0.05 as compared to veh + 5XE4; n = 9–10. LRP-1 changes in mice brain homogenate were assessed through, B western blot for LRP-1 and oxi-LRP-1 expression; C quantification of expression LRP-1 and oxi-LRP-1. Data is presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, a- as compared to veh + WT, b- as compared to veh + 5XE4; n = 4 for western blot analysis; veh- vehicle, WT- wild-type, 5XE4- 5XFAD/APOE4