Fig. 9

Quantitation of lumbar spinal cord microglial cells of different morphologies in mice injected intraperitoneally with assembled A53T α-synuclein or with MSA brain extract. One month after injection of assembled A53T α-synuclein or control cerebellar extracts, most microglial cells were ramified. At 3 months after injection of assembled A53T α-synuclein, there was an increase in dystrophic microglia. At 5 months after injection of assembled A53T α-synuclein and in end-stage mice injected with MSA cerebellar extracts, dystrophic microglia predominated and ramified microglia were almost absent