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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Fig. 8

Microglia and α-synuclein inclusions in 20-month-old M83 +/+ mice. A Iba1-immunoreactive microglial cells envelop nerve cells immunoreactive with an antibody specific for pS129 α-synuclein (ab184674). B Cells stained by pFTAA are also immunoreactive for pS129 α-synuclein (EP1536Y). C Iba1-immunoreactive microglial cells envelop nerve cells stained by pFTAA. D Iba1-immunoreactive microglial cells envelop nerve cells stained by an antibody specific for residues 34–45 of α-synuclein (α-Syn34-45, BioLegend). E Iba1-immunoreactive microglial cells envelop nerve cells stained by an antibody specific for residues 80–96 of α-synuclein (α-Syn80-96, BioLegend). F Iba1-immunoreactive microglial cells envelop nerve cells stained by an antibody specific for residues 117–122 of α-synuclein (α-Syn117-122, BioLegend). Scale bars, 100 μm. (019–9741 Wako was used for all Iba1 stainings)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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