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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Fig. 7

Synucleinopathy in M83± mice following intraperitoneal injection of cerebellar extracts from an individual with neuropathologically confirmed MSA. A Staining of midbrain periaqueductal grey (PAG) and lumbar spinal cord (ventral horn) for pS129 α-synuclein (Wako pSyn#64). Arrows denote perikaryal and arrowheads neuritic staining. Scale bars, 50 μm. B Immunoblots of sarkosyl-insoluble material from brain and spinal cord using an antibody specific for pS129 α-synuclein (Abcam ab51253). C Motor neuron numbers in lumbar spinal cord following intraperitoneal injection of extracts from control and MSA cerebellum. Comparison with uninjected mice. The number of motor neurons of mice injected with extracts from control cerebellum was taken as 100%. One-way ANOVA F(3,16) = 127.5, followed by Tukey’s multiple comparisons test. ****p < 0.0001 (n = 5)

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