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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Fig. 6

Type II α-synuclein filaments extracted from MSA cerebellum. A Staining by ab1903 of abundant neuronal and glial α-synuclein inclusions in cerebellar white matter. Scale bar, 100 μm. B Negative-stain immunoelectron microscopy of α-synuclein filaments extracted from MSA cerebellum. Ab59264 was used. Scale bar, 200 nm. C Negative-stain electron microscopy of twisted α-synuclein filament. Scale bar, 50 nm. D Reference-free 2D class average spanning an entire crossover of filaments extracted from MSA cerebellum. Only type II filaments were present. E Cryo-EM map of type II filaments from MSA cerebellum

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