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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau

Fig. 2

Retinal tissue of patient #2 showing outer nuclear layer (ONL) loss, correlation to ONL thinning seen on optical coherence tomography, and associated brain pathology. Left eye retina tissue from macula a (H & E, original magnification X 5). Box shows corresponding area of higher magnification b (original magnification X 20). There is a significant area of ONL thinning (black arrow) with only 2–4 layers of nuclei. Other retinal layers have no abnormalities except for mild tissue processing artifact. There is no artifact affecting ONL nuclei. Full retina examination prior to expiration showed a normal appearing macula with no confounding retinal disease. OCT at that time also showed macula ONL thinning. c shows the ETDRS grid location of inferior parafoveal OCT scans d, e (green line) and of point measurements (red asterisk). d shows OCT of an age, sex, race matched normal control with normal ONL thickness in comparison to ONL thinning seen on this patient’s OCT (e). Brain pathology displayed tau pathology consisting of pretangles (f), tangles (f), grains (f, g) and white matter coiled bodies (g) consistent with frontotemporal dementia with parkinsonism linked to chromosome 17. MRI (h, i, j) showed severe widespread frontotemporal atrophy bilaterally. GCL ganglion cell layer, INL inner nuclear layer, ONL outer nuclear layer

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