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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density

Fig. 1

Overexpression of Lin28A in neural precursor cells does not lead to brain tumor formation. a-j, p-y H&E stained sagittal (a-e, p–t) and frontal (f-j, u-y) brain sections. Control (CTRL) (a-o) and GL (p-ad) mice did not display tumor formation in the forebrain or hindbrain on embryonic day 14.5 (E14.5), postnatal day 0 (P0), P15, P30 and up to P200. No abnormalities of foliation or cortical layering were detected in the cerebellum (insets in e and t). LIN28A stained mouse brains show a strong LIN28A expression in GL (z-ad) but not in CTRL mice (k–o). Scale bar in a is 1 mm for a and p; scale bar in b is 2.0 mm for b and q; scale bar in c is 2.5 mm for c-e and r-t; scale bar in f is 0.5 mm for f and u; scale bar in g is 2.0 mm for g and v; scale bar in h is 2.5 mm for h-j and w-y; scale bar in k is 50 µm for k and z; scale bar in l is 50 µm for l and aa; scale bar in m is 100 µm for m–o and ab-ad; FB = forebrain, CB = cerebellum, * = hippocampus

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