Fig. 1From: Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine densityOverexpression of Lin28A in neural precursor cells does not lead to brain tumor formation. a-j, p-y H&E stained sagittal (a-e, p–t) and frontal (f-j, u-y) brain sections. Control (CTRL) (a-o) and GL (p-ad) mice did not display tumor formation in the forebrain or hindbrain on embryonic day 14.5 (E14.5), postnatal day 0 (P0), P15, P30 and up to P200. No abnormalities of foliation or cortical layering were detected in the cerebellum (insets in e and t). LIN28A stained mouse brains show a strong LIN28A expression in GL (z-ad) but not in CTRL mice (k–o). Scale bar in a is 1 mm for a and p; scale bar in b is 2.0 mm for b and q; scale bar in c is 2.5 mm for c-e and r-t; scale bar in f is 0.5 mm for f and u; scale bar in g is 2.0 mm for g and v; scale bar in h is 2.5 mm for h-j and w-y; scale bar in k is 50 µm for k and z; scale bar in l is 50 µm for l and aa; scale bar in m is 100 µm for m–o and ab-ad; FB = forebrain, CB = cerebellum, * = hippocampusBack to article page