Fig. 7
From: RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Single channel analysis and [3H]-binding of the RyR1-RM patient-related Ca2+ binding site mutants. A Representative single channel traces of WT RyR1 and Q3970K under 150 nM Ca2 + , 10 µM Ca2+, or 10 mM Ca2+. B Po versus Ca2+ concentration curve. C [3H]-ryanodine binding to ER microsomes of HEK293 cells expressing WT RyR1 and Q3970K mutant. Data are presented as mean ± S.E.M from 6 single channels for each group