Fig. 4From: RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulationStructure of the calcium binding site. A ribbon structure of the Ca2+ binding site showing interacting residues. B [3H]-ryanodine binding to ER microsomes of HEK293 cells expressing WT RyR1 and calcium binding site mutants. Data are presented as mean ± S.E.M from 6 single channels for each group. **P < 0.01Back to article page