Fig. 4
From: Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis
Differential expression analysis between the transcription factor related groups. a Overview of the differentially expressed genes and their secretome class according the Human Protein Atlas (www.proteinatlas.org). b Top 30 differentially expressed genes sorted according to their respective log fold change. c Barplot of the expression levels of the top five differentially expressed genes in each TF-related comparison. d Immunohistochemistry examples of differentially expressed proteins between TF classes of PitNETs. FKBP10 (top) shows a distinct cytoplasmic positivity in a PIT1 tumor as compared to TPIT and SF1. IGSF1 (middle) shows a clear and general membraneous positivity in PIT1 tumor cells, whereas only few cells appear positive in a TPIT and a SF1 tumor. IDH1 (bottom) shows a distinct cytoplasmic positivity in a SF1 tumor compared to negative staining in a TPIT and a PIT tumor. Magnification corresponds to 200 × for all the microphotographs