Fig. 3
From: Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis
Correlation network analysis. a A network visualization showing the Spearman correlation between transcription factors (SF1, PIT1 and TPIT) and the six pituitary hormones (GH, PRL, TSH, LH, FSH and ACTH). b A network visualization showing the top fifteen neighbors based on Spearman correlation connected to transcription factors (SF1, PIT1 and TPIT) and six pituitary hormones (GH, PRL, TSH, LH, FSH and ACTH). c Immunohistochemistry using antibodies recognizing IKBIP (top) and ACSL1 (bottom) in three different PitNETs representing the three TF classes of PitNETs. IKBIP, correlating with PIT1, shows strong positivity in PIT1 tumor cells whereas tumor cells in TPIT and SF1 tumors are essentially negative. ACSL1, correlating with TPIT, shows positivity in a TPIT tumor whereas PIT1 and SF1 tumors appear negative or only faintly positive. Magnification corresponds to 200 × for all the microphotographs