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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Fig. 6

LRRK2 inhibition reduces relative distance between α-synuclein and vGLUT1 in the mouse striatum A Confocal microscope images of the striatum in non-expanded, 2.4x, and 4.8 × expanded brain sections immunostained for α-synuclein (green), vGLUT1 (red) and Homer1 (blue). Scale bar = 10 µm. B Representative synapses upon control and LRRK2 kinase inhibitor treatment (7 days, 10 nM MLi-2). Scale bar = 2 µm. C Respective fluorescent profiles from B. D Quantification of distance measurements in mean distance (± SEM) between Homer1 and vGLUT1 (t(4) = 0.6) and between vGLUT1 and α-synuclein (t(4) = 5.3 (nested t-test analysis, n = 3, 25 measurements per n. **P < 0.01

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