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Table 1 List of identified peptides derived from r-αSyn incubated with CK2 and ATP for 7 days

From: Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2

Query

Start

End

Observed

Mr(expt)

Mr(calc)

ppm

Score

Expect

Peptide

WT

5284

44

58

802.9034

1603.792

1603.797

 − 2.97

65

3.5E−07

K.TpKEGVVHGVATVAEK.T

11012

46

80

1172.286

3513.836

3513.808

8.02

51

8.4 E−06

K.EGVVHGVATpVAEKTKEQVTN*VGGAVVTGVTAVAQK.T

8325

59

80

746.3851

2236.134

2236.147

 − 5.77

47

0.000021

K.TKEQVTpNVGGAVVTGVTAVAQK.T

8336

59

80

1120.068

2238.122

2238.115

3.44

21

0.0083

K.TpKEQ*VTN*VGGAVVTGVTAVAQK.T

11170

59

96

924.9822

3695.9

3695.914

 − 3.77

76

2.4 E−08

K.TpKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVK.K

5009

81

96

779.8777

1557.741

1557.744

 − 1.95

88

1.6 E−09

K.TVEGAGSpIAAATGFVK.K

12198

98

140

1228.245

4908.951

4908.947

0.96

20

0.011

K.DQLGKN*EEGAPQEGILEDMPVDPDN*EAYEMPSpEEGYQDYEPEA

12214

98

140

1232.002

4923.98

4923.958

4.6

34

0.00044

K.DQLGKN*EEGAPQEGILEDMoPVDPDNEAYEMPSEEGYQDYpEPEA

12225

98

140

1235.754

4938.985

4938.969

3.36

21

0.01

K.DQLGKNEEGAPQEGILEDMoPVDPDNEAYEMoPSEEGYQDYpEPEA

12226

98

140

1235.756

4938.994

4938.969

5.24

30

0.0011

K.DQLGKNEEGAPQEGILEDMoPVDPDNEAYpEMoPSEEGYQDYEPEA

12228

98

140

1236.002

4939.979

4939.953

5.31

23

0.0073

K.DQLGKNEEGAPQEGILEDMoPVDPDN*EAYEMoPSEEGYQDYpEPEA

12229

98

140

1236.003

4939.982

4939.953

5.91

26

0.0032

K.DQ*LGKNEEGAPQEGILEDMoPVDPDNEAYEMoPSEEGYQDYpEPEA

11769

103

140

1092.433

4365.703

4365.693

2.34

21

0.0077

K.NEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYpEPEA

11770

103

140

1456.242

4365.704

4365.693

2.61

18

0.017

K.NEEGAPQEGILEDMPVDPDNEAYEMPSpEEGYQDYEPEA

11805

103

140

1461.57

4381.688

4381.688

0.11

24

0.004

K.NEEGAPQEGILEDMPVDPDNEAYEMoPSpEEGYQDYEPEA

11806

103

140

1461.572

4381.693

4381.688

1.19

22

0.0069

K.NEEGAPQEGILEDMPVDPDNEAYEMoPSpEEGYQDYEPEA

11807

103

140

1461.572

4381.694

4381.688

1.45

28

0.0015

K.NEEGAPQEGILEDMoPVDPDNEAYEMPSpEEGYQDYEPEA

11808

103

140

1096.431

4381.696

4381.688

1.93

25

0.0034

K.NEEGAPQEGILEDMPVDPDNEAYEMoPSpEEGYQDYEPEA

11809

103

140

1461.576

4381.707

4381.688

4.54

28

0.0017

K.NEEGAPQEGILEDMPVDPDNEAYEMoPSpEEGYQDYEPEA

11851

103

140

1100.425

4397.671

4397.682

 − 2.69

31

0.00073

K.NEEGAPQEGILEDMoPVDPDNEAYEMoPSpEEGYQDYEPEA

11855

103

140

1466.906

4397.696

4397.682

3.13

31

0.00086

K.NEEGAPQEGILEDMoPVDPDNEAYEMoPSEEGYQDYpEPEA

11856

103

140

1466.908

4397.701

4397.682

4.29

24

0.004

K.NEEGAPQEGILEDMoPVDPDNEAYEMoPSEEGYQDYpEPEA

11870

103

140

1467.57

4399.687

4399.651

8.37

24

0.0039

K.NEEGAPQEGILEDMoPVDPDN*EAYEMoPSpEEGYQDYEPEA

S129A

3243

11

23

691.3577

1380.701

1380.701

 − 0.32

28

0.0014

K.AKEGVVAAAEKTpK.Q

1528

22

32

570.2711

1138.528

1138.538

 − 9.45

46

0.000028

K.TpKQGVAEAAGK.T

4891

44

58

802.8981

1603.782

1603.797

 − 9.67

60

9.1 E−07

K.TpKEGVVHGVATVAEK.T

3201

46

58

688.3341

1374.654

1374.654

 − 0.57

42

0.00006

K.EGVVHGVATpVAEK.T

8000

59

80

1119.079

2236.144

2236.147

 − 1.15

64

4.2 E−07

K.TpKEQVTNVGGAVVTGVTAVAQK.T

8001

59

80

746.3887

2236.144

2236.147

 − 1.02

25

0.003

K.TKEQVTNVGGAVVTGVTpAVAQK.T

5372

81

97

843.9226

1685.831

1685.839

 − 4.98

52

6.4 E−06

K.TVEGAGSpIAAATGFVKK.D

  1. p indicates phosphorylation sites; o indicates oxidation site
  2. *Indicates deamidation site