Fig. 2
From: P62 accumulates through neuroanatomical circuits in response to tauopathy propagation
Tau transfer and clearance dysfunction in the EC-Tau mouse. a Tau pathology spread in the EC-Tau Mouse from the lateral EC to the frontal cortex. Image source: Allen brain atlas. b–c Immunofluorescence images: MC1 (green), p62 (white) and DAPI (blue) staining in EC-Tau mice with mild (upper panel), moderate (middle panel) and severe (bottom panel) pathology for the EC (b) and the CA3 (c). Scale bar represents 30 μm. d–e DAB staining of the hippocampus, entorhinal and frontal cortices on EC-Tau mice with mild (upper panel), moderate (middle panel) and severe (bottom panel) pathology for MC1 (d) and p62 (e). Scale bar represents 200 μm. f–g Quantification of the number of positive neurons is shown for MC1 (f) and p62 (g) for the dentate gyrus, CA1, CA3, subiculum and the entorhinal, perirhinal and frontal cortices. Absolute numbers, one-way ANOVA with post-hoc test for each region. h Correlation between the number of MC1 and p62 positive neurons in the EC-Tau mice and for each measured region