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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: A novel SMARCA2-CREM fusion: expanding the molecular spectrum of intracranial mesenchymal tumors beyond the FET genes

Fig. 1

Radiological and histopathological features of the recurrent tumor A Coronal T1-weighted magnetic resonance imaging sequence after contrast injection showing an enhancing extra-axial right parietal mass with necrotic component and dural tail. B Axial Fluid attenuated inversion recovery (FLAIR) sequence showing a perilesional edema. C Axial T2*-weighted sequence showing anterior hemorrhagic modifications (low-intensity areas). D Infiltration of the brain parenchyma by tumor cells (HPS, magnification × 400). E Collagen deposits in the tumor (HPS, magnification × 400). F Proliferation composed of epithelioid cells with intranuclear pseudoinclusions (white arrowhead) and several mitoses (black arrowhead) and elevated MIB-1 labeling index (HPS, magnification × 400, and insert MIB-1 magnification × 400). G Clear cell component (HPS, magnification × 400). H Necrosis (HPS, magnification × 400). (I) Chordoid inflexion (HPS, magnification × 400). J Peritumoral inflammatory infiltrates (HPS, magnification × 100). K EMA immunoexpression by tumor cells (magnification × 400). L Desmin immunoexpression by tumor cells (magnification × 400). Black scale bars represent 50 µm for figures D-I and K-L; and 250 µm for figure J. HPS: Hematoxylin Phloxin Saffron

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