Table 2 RT-QuIC seeding profiles in PD stratified by mutation status

Male sex %

70

70

65

66

33

41

33

0.096

Age (y)

65 ± 8

65 ± 9

66 ± 9

59 ± 10

65 ± 13

62 ± 13

63 ± 9

0.070

Age at onset (y)

61 ± 8

58 ± 10

57 ± 9

51 ± 10

53 ± 14

51 ± 13

36 ± 6

 ≤ 0.001

Disease Duration (y)

5 ± 3

8 ± 5

8 ± 6

9 ± 7

12 ± 7

11 ± 10

27 ± 2

 ≤ 0.001

UPDRS III

23 ± 10

28 ± 11

28 ± 13

27 ± 13

27 ± 9

27 ± 11

22 ± 1

0.265

MoCA

26 ± 3

24 ± 5

25 ± 6

24 ± 5

24 ± 4

26 ± 3

27 ± 5

0.005

LEDD

389 ± 259

595 ± 363

626 ± 252

701 ± 545

802 ± 399

830 ± 1241

1497 ± 1481

RT-QuIC positive (%)

97 (91)

48 (91)

11 (65)

27 (93)

7 (78)

10 (59)

0 (0)

 ≤ 0.001

RT-QuIC 0/4 positive (%)

10 (9)

5 (9)

6 (35)

2 (7)

2 (22)

7 (41)

3 (100)

 ≤ 0.001

RT-QuIC 2/4 positive (%)

13 (12)

1 (2)

1 (6)

0 (0)

0 (0)

3 (18)

0 (0)

RT-QuIC 3/4 positive (%)

29 (27)

11 (21)

3 (18)

5 (17)

3 (33)

3 (18)

0 (0)

RT-QuIC 4/4 positive (%)

55 (52)

36 (68)

7 (41)

22 (76)

4 (45)

4 (23)

0 (0)

RT-QuIC AUC

713 ± 238

795 ± 281

797 ± 157

858 ± 179

843 ± 191

702 ± 202

n.a

0.048

RT-QuIC Imax

68 ± 14

71 ± 15

72 ± 12

71 ± 10

75 ± 7

67 ± 12

n.a

0.378

RT-QuIC LAG

21 ± 3

20 ± 3

20 ± 2

19 ± 2

19 ± 3

21 ± 2

n.a

0.009

CSF total

α-Syn pg/ml

578 ± 279

560 ± 212

489 ± 220

512 ± 273

712 ± 319

567 ± 221

840 ± 487

0.171

CSF Aβ_1–42 pg/ml

679 ± 249

684 ± 268

706 ± 214

779 ± 248

972 ± 302

753 ± 299

854 ± 262

0.208

CSF t-Tau pg/ml

232 ± 127

265 ± 152

241 ± 100

203 ± 86

334 ± 190

261 ± 144

179 ± 19

0.191

CSF p-Tau pg/ml

41 ± 16

39 ± 12

43 ± 15

36 ± 16

54 ± 21

45 ± 20

42 ± 6

0.227

NFL pg/ml

894 ± 633

1042 ± 1320

1099 ± 965

839 ± 635

832 ± 311

720 ± 419

571 ± 87

0.816