Table 1 RT-QuIC seeding profiles stratified by diagnosis

Male Sex %

65

70

0.237

54

36

0.271

Age (y)

64 ± 9

72 ± 7***

 ≤ 0.001

59 ± 12

58 ± 15

0.855

Age at onset (y)

57 ± 10

68 ± 7***

–

–

–

–

Disease duration (y)

7 ± 6

3 ± 2***

–

–

–

–

UPDRS III

25 ± 11

30 ± 13*

 ≤ 0.001

2 ± 2

1 ± 1

0.112

MoCA

25 ± 4

15 ± 6***

 ≤ 0.001

27 ± 3

28 ± 2

0.303

LEDD

544 ± 475

392 ± 216*

–

–

–

RT-QuIC positive seeding n (%)

200 (85)

42 (86)

 ≤ 0.001

2 (8)

2 (14)

0.516

RT-QuIC 0/4 positive seeding n (%)

35 (15)

7 (14)

 ≤ 0.001

18 (92)

12 (86)

0.363

RT-QuIC 2/4 positive seeding n (%)

18 (8)

1 (2)

1 (4)

0

RT-QuIC 3/4 positive seeding n (%)

54 (23)

12 (25)

0

1 (7)

RT-QuIC 4/4 positive seeding n (%)

128 (54)

29 (59)

1 (4)

1 (7)

RT-QuIC AUC

761 ± 239

804 ± 225

–

–

–

–

RT-QuIC Imax

70 ± 13

69 ± 12

–

–

–

–

RT-QuIC LAG

21 ± 3

20 ± 3

–

–

–

–

CSF total alpha-synuclein pg/ml

567 ± 262

535 ± 322*

0.175

583 ± 181

627 ± 389

0.677

CSF Aβ_1–42 pg/ml

713 ± 262

518 ± 229**

 ≤ 0.001

925 ± 231

885 ± 407

0.693

CSF t-Tau pg/ml

242 ± 132

328 ± 238

0.151

240 ± 97

242 ± 120

0.955

CSF p-Tau pg/ml

41 ± 16

49 ± 28

0.429

41 ± 13

44 ± 17

0.561

NFL pg/ml

917 ± 850

1921 ± 1888***

 ≤ 0.001

542 ± 239

431 ± 91

0.294